Electroanalysis of Ranitidine (RAN) in Pharmaceutical Formulations and Biological Samples at Modified Electrodes

C. Narasimha Rao¹, K. Balaji¹, C. Narasimha Rao² and P. Venkateswarlu¹*

¹Department of Chemistry, Sri Venkateswara University, Tirupati-517 502 (India). 

²Department of Zoology, Sri Venkateswara University, Tirupati-517 502 (India).

DOI : http://dx.doi.org/10.13005/msri/050208

ABSTRACT:

A sensitive differential pulse voltammetric (DPV) method for the determination of Ranitidine (RAN) at bare carbon paste electrode (CPE) and zeolite modified carbon paste electrode (ZMCPE) was developed. Compared to bare carbon paste electrode (CPE), ZMCPE exhibited increased sensitivity. Quantitative determination was achieved in the concentration range of 6.2 x 10-8 M to 4.4 x 10-7 M and 1.2 x 10-9 to 2.2 x 10-8 M for CPE and ZMCPE respectively. LOD and LOQ were found to be 1.9 x 10-8 and 0.633 x 10-7 M; 3.1 x 10-9 M and 1.03 x 10-8 M for CPE and ZMCPE respectively. Factors affecting peak currents such as accumulation time, accumulation potential, pH of buffer solution were examined. The proposed method has been successfully applied for the determination of RAN in pharmaceutical formulations and biological samples.

KEYWORDS: Ranitidine; differintial pulse voltammetry; cyclic voltammetry; zeolite

Copy the following to cite this article: Rao C. N, Balaji K, Rao C. N, Venkateswarlu P. Electroanalysis of Ranitidine (RAN) in Pharmaceutical Formulations and Biological Samples at Modified Electrodes. Mat.Sci.Res.India;5(2)

Copy the following to cite this URL: Rao C. N, Balaji K, Rao C. N, Venkateswarlu P. Electroanalysis of Ranitidine (RAN) in Pharmaceutical Formulations and Biological Samples at Modified Electrodes. Mat.Sci.Res.India;5(2). Available from: http://www.materialsciencejournal.org/?p=2028

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